Click chemistry: In vitro evaluation of glycosyl hybrid phosphorylated/thiophosphorylated 1,2,3-triazole derivatives as irreversible acetyl cholinesterase (AChE) inhibitors

Results in Chemistry

Tanima Bajaj¹  B. Anjaneyulu²  G.B. Dharma Rao³ 

[1] Corresponding author at: Department of Chemistry, Kommuri Pratap Reddy Institute of Technology, Hyderabad 500088, Telangana, India.;Department of Chemistry, Faculty of Science, Shree Guru Gobind Singh Tricentenary University, Haryana 122505, India;Department of Chemistry, Kommuri Pratap Reddy Institute of Technology, Hyderabad 500088, TS, India;

关键词: Glucosides;    1,2,3-Triazole;    Click chemistry;    Organophosphorous;    Cycloaddition;   

DOI  :  

来源: DOAJ

【 摘 要 】

A novel series of phosphorylated/ thiophosphorylated glucosyl-1,2,3-triazole derivatives have been synthesized in three step process. The synthetic approach was progressed from the reaction of propargyl alcohol with dialkoxychlorophosphate/thiophosphate derivatives to give propargylphosphate/thiophosphate derivatives. Then, the reaction of above synthesized compounds with acetylated glucosyl azides through azide-alkyne [2 + 3]-cycloaddition reaction (click reaction) led to the formation of the title phosphorylated/thiophosphorylated glucosyl-1,2,3-triazole derivatives in good yields. The synthesized compounds are subjected to biological evaluation as acetyl cholinesterase (AChE) inhibitors and the results are compared with reported compounds.

【 授权许可】

Unknown