Parallel synthesis of a bis-triazoles library as psammaplin A analogues: A new wave of antibiofilm compounds?

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:29

Article

Andjouh, Sofyane¹  Blache, Yves¹ 

[1] Univ Toulon & Var, MAPIEM, Toulon, France

关键词: Anti-biofilm;    1,2,3-Triazole;    Psammaplin A;    Click chemistry;   

DOI  :  10.1016/j.bmcl.2018.12.047

来源: Elsevier

【 摘 要 】

Synthesis of psammaplin A analogues is described. Screening for antibiofilm activity of the targeted library afford some interesting elements in terms of structure-activity relationships. Some compounds exhibited EC50 in the range of ampicillin against three strains of gramnegative bacteria without toxic effect.

【 授权许可】

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