Best practice considerations for using the selectivity factor, s, as a metric for the efficiency of kinetic resolutions

TETRAHEDRON

卷:74

Article

Greenhalgh, Mark D.¹  Taylor, James E.¹  Smith, Andrew D.¹ 

[1] Univ St Andrews, Sch Chem, EaStCHEM, St Andrews KY16 9ST, Fife, Scotland

关键词: Kinetic resolution;    Selectivity factor;    Data analysis;    Error calculations;    HPLC analysis;   

DOI  :  10.1016/j.tet.2018.05.069

来源: Elsevier

【 摘 要 】

The suitability of using the selectivity factor, s, as a metric for kinetic resolution reactions and the errors associated with its measurement are considered. Investigation of the analytical error associated with HPLC analysis of a kinetic resolution reveals that one of the largest potential sources of variation arises from the ability of a practitioner to integrate the peaks from a single analysis. The consequences of this error on the reliability of reported s values are discussed, and some general rules for good practice regarding the use and reporting of s as a metric are suggested. (C) 2018 Elsevier Ltd. All rights reserved.

【 授权许可】

Free