Direct regioselective Csp2-H trifluoromethylation of pyrimidinones and pyridinones

TETRAHEDRON

卷:72

Article

Zhang, Pei-Zhi¹  Li, Cheng-Kun¹  Zhang, Guo-Yu¹  Zhang, Ling¹  Jiang, Yao-Jia³  Zou, Jian-Ping^1,2 

[1] Soochow Univ, Coll Chem & Chem Engn, Key Lab Organ Synth Jiangsu Prov, 199 Renai St, Suzhou 215123, Jiangsu, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Synthet Chem Nat Subst, Shanghai 200032, Peoples R China

[3] Nanjing Tech Univ, Coll Chem & Mol Engn, IAM, Nanjing 21009, Jiangsu, Peoples R China

关键词: Trifluoromethylation;    Radical reaction;    Pyrimidinone;    Pyridinone;   

DOI  :  10.1016/j.tet.2016.04.048

来源: Elsevier

【 摘 要 】

A direct regioselective C-sp2-H trifluoromethylation of pyrimidinones and pyridinones using CF3SO2Na/Mn(OAc)(3) to afford 5-trifluoromethyl pyrimidinones and 3-trifluorornethyl pyridinones in moderate to good yields was described. The reaction showed that the steric hindrance due to bulky groups adjacent to the position of attack by the trifluoromethyl radical had important influence on the yield. (c) 2016 Elsevier Ltd. All rights reserved.

【 授权许可】

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