Research progress on trifluoromethyl-based radical reaction process

1st International Global on Renewable Energy and Development

Song, Hao^1

College of Chemistry, Jilin University, Jilin, 130012, China^1

关键词: Carbon-carbon bond-forming reactions;    High-electron-density;    Metabolic stability;    Organic materials;    Radical reactions;    Structural motifs;    Trifluoromethyl group;    Trifluoromethylation;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/100/1/012061/pdf
DOI  :  10.1088/1755-1315/100/1/012061

来源: IOP

【 摘 要 】

Due to the unique properties imparted by the trifluoromethyl group, such as high electron density and strong lipotropy, which effectively improve acidity, lipophilicity and metabolic stability of the molecule itself, trifluoromethyl-substituted organic compounds are becoming increasingly important as structural motifs in pharmaceuticals, agrochemicals and organic materials. In this review, we present several methods developed for the direct introduction of a trifluoromethyl group, beginning with its rich and storied history. Then the present article addresses mechanism and process in carbon-carbon bond forming reaction based on radical process which is divided into three parts according to the way of CF3radical generation. Finally, challenges and opportunities of researches on trifluoromethylation reactions facing are prospected.