Synthesis and evaluation of N6-substituted azide- and alkyne-bearing N-mustard analogs of S-adenosyl-L-methionine

TETRAHEDRON

卷:70

Article

Ramadan, Mohamed¹  Bremner-Hay, Natalie K.¹  Carlson, Steig A.¹  Comstock, Lindsay R.¹ 

[1] Wake Forest Univ, Dept Chem, Winston Salem, NC 27106 USA

关键词: S-Adenosyl-L-methionine;    DNA methyltransferase;    SAM analog;    N-Mustard;   

DOI  :  10.1016/j.tet.2014.05.055

来源: Elsevier

【 摘 要 】

The synthesis of a family of N-mustard analogs of S-adenosyl-L-methionine (SAM) containing azides and alkynes at the N6-position of the adenosine base has been accomplished from commercially available inosine. Further biochemical analysis of these analogs indicates successful modification of pUC19 plasmid DNA in an enzyme-dependent fashion with DNA methyltransferases M.TaqI and M.Hhal. (C) 2014 The Authors. Published by Elsevier Ltd.

【 授权许可】

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