Synthesis and functional evaluation of chiral dendrimer-triamine-coordinated Gd complexes with polyaminoalcohol end groups as highly sensitive MRI contrast agents

TETRAHEDRON

卷:71

Article

Miyake, Yuka¹  Kimura, Yu^1,2  Orito, Naomi¹  Imai, Hirohiko³  Matsuda, Tetsuya³  Toshimitsu, Akio^1,4  Kondo, Teruyuki^1,5 

[1] Kyoto Univ, Grad Sch Engn, Dept Energy & Hydrocarbon Chem, Nishikyo Ku, Kyoto 6158510, Japan

[2] Kyoto Univ, Ctr Promot Interdisciplinary Educ & Res, Res & Educ Unit Leaders Integrated Med Syst, Kyoto 6158510, Japan

[3] Kyoto Univ, Grad Sch Informat, Sakyo Ku, Kyoto 6068501, Japan

[4] Kyoto Univ, Inst Chem Res, Div Multidisciplinary Chem, Uji, Kyoto 6110011, Japan

[5] Kyoto Univ, Ctr Promot Interdisciplinary Educ & Res, Adv Biomed Engn Res Unit, Kyoto 6158510, Japan

关键词: Chiral dendrimer;    MRI contrast agent;    Gadolinium;    Polyethylene glycol;    Molecular imaging;   

DOI  :  10.1016/j.tet.2015.04.050

来源: Elsevier

【 摘 要 】

Novel chiral dendrimer-triamine-coordinated Gd complexes with polyaminoalcohol end groups were synthesized and shown to have longitudinal relaxivity (r(1)) values 5 times higher than that of clinically used Gd-DTPA. The affinities of Gd-4a and Gd-4b for bovine serum albumin (BSA), respectively, were estimated by a quartz crystal microbalance (QCM) measurement. The amino groups of the dendrimer were then conjugated with PEG. This conjugation with PEG strongly affected its ability to attenuate signals in T-1-weighted MRI. (C) 2015 Elsevier Ltd. All rights reserved.

【 授权许可】

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