Mesoporous Silica Nanoparticles with Co-Condensed Gadolinium Chelates for Multimodal Imaging

Nanomaterials

Kathryn M. L. Taylor-Pashow¹  Joseph Della Rocca² 

[1] Savannah River National Laboratory, Savannah River Site, Bldg. 773-A, Aiken, SC 29808, USA;Department of Chemistry, CB #3290, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA;

关键词: mesoporous silica nanoparticle;    MRI contrast agent;    Gd³⁺ contrast agent;    multimodal imaging;   

DOI  :  10.3390/nano2010001

来源: mdpi

【 摘 要 】

Several mesoporous silica nanoparticle (MSN) contrast agents have been synthesized using a co-condensation method to incorporate two different Gd³⁺ complexes at very high loadings (15.5–28.8 wt %). These MSN contrast agents, with an MCM-41 type pore structure, were characterized using a variety of methods including SEM and TEM, nitrogen adsorption measurements, thermogravimetric analysis (TGA), direct current plasma (DCP) spectroscopy, and powder X-ray diffraction (PXRD). The magnetic resonance (MR) relaxivities of these contrast agents were determined using a 3 T MR scanner. The r₁ relaxivities of these nanoparticles range from 4.1 to 8.4 mM⁻¹s⁻¹ on a per Gd basis. Additionally, the MSN particles were functionalized with an organic fluorophore and cancer cell targeting peptide to allow for demonstration of both the optical and MR contrast enhancing capabilities in vitro.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.