Nickel-catalyzed dual C-C σ bond activation to construct carbocyclic skeletons

TETRAHEDRON

卷:71

Article

Nakai, Kenichiro¹  Kurahashi, Takuya^1,2  Matsubara, Seijiro¹ 

[1] Kyoto Univ, Grad Sch Engn, Dept Chem Mat, Nishikyo Ku, Kyoto 6158510, Japan

[2] ACT C, JST, Kawaguchi, Saitama 3320012, Japan

关键词: C-C bond activation;    Nickel catalyst;    Heterocyclic compound;    Carbocyclic compound;   

DOI  :  10.1016/j.tet.2015.02.064

来源: Elsevier

【 摘 要 】

A nickel/Lewis acid catalyzed intermolecular cycloaddition reaction of o-cyanobenzylarylketones with allcynes to form naphthalenones is developed. This reaction is promoted by the nickel/Lewis Acid catalyst pair and involves the cleavage of two C-C sigma bonds to eliminate arylcyanide and the formation of different two C-C sigma bonds with alkyne insertion. (C) 2015 Elsevier Ltd. All rights reserved.

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