Synthesis of C-C bonded dimeric steroids by olefin metathesis

TETRAHEDRON

卷:65

Article

Burton, Gerardo¹ 

[1] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Quim Organ, RA-1428 Buenos Aires, DF, Argentina

关键词: Dimerization;    Metathesis;    Dimeric steroids;    Microwave;   

DOI  :  10.1016/j.tet.2009.03.006

来源: Elsevier

【 摘 要 】

Five new C-C bonded steroidal homodimers derived from deoxycholic acid, pregnenolone, and progesterone were synthesized by an olefin metathesis reaction assisted by microwave heating. Microwave improved the yield and accelerated the reaction allowing the use of less catalyst with good results (25 mol %). Due to the bulky nature of the steroidal skeleton the more favorable E-dimers were formed as the sole or major products depending on the linker length. (C) 2009 Elsevier Ltd. All rights reserved.

【 授权许可】

Free