Ruthenium-catalyzed olefin metathesis after tetra-n-butylammonium fluoride-mediated desilylation

TETRAHEDRON LETTERS

卷:53

Article

Osman, Sami¹  Koide, Kazunori¹ 

[1] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA

关键词: Metathesis;    Ruthenium;    Fluoride;    Silicon;    One-pot;   

DOI  :  10.1016/j.tetlet.2012.09.035

来源: Elsevier

【 摘 要 】

One-pot procedures expedite organic synthesis but pose challenges in that many reagents must be compatible with each other. We discovered that the presence of (Bu4NF)-Bu-n hindered ruthenium-catalyzed olefin metathesis when (Bu4NF)-Bu-n-mediated desilylation and olefin metathesis were performed in one pot. This problem could be solved by the addition of (TMS)(2)O to remove fluoride anions in order to facilitate the ruthenium-catalyzed olefin metathesis. (c) 2012 Elsevier Ltd. All rights reserved.

【 授权许可】

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