Total synthesis of lamellarins D, L, and N

TETRAHEDRON

卷:62

Article

Fujikawa, N ; Ohta, T ; Yamaguchi, T ; Fukuda, T ; Ishibashi, F ; Iwao, M

关键词: total synthesis;    lamellarin;    Hinsberg reaction;    Suzuki-Miyaura coupling;   

DOI  :  10.1016/j.tet.2005.10.014

来源: Elsevier

【 摘 要 】

Total synthesis of cytotoxic marine alkaloids, lamellarins D, L, and N, has been achieved by using Hinsberg-type pyrrole synthesis and palladium-catalyzed Suzuki-Miyaura coupling of the 3,4-dihydroxypyrrole bistriflate 6 as the key reactions. The total yields of lamellarins D, L, and N from the common intermediate 6 are 54, 58, and 50%, respectively. (c) 2005 Elsevier Ltd. All rights reserved.

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