Catalytic enantioselective alkene epoxidation using novel spirocyclic N-carbethoxy-azabicyclo[3.2.1]octanones

TETRAHEDRON

卷:66

Article; Proceedings Paper

Armstrong, Alan¹  Bettati, Michela¹  White, Andrew J. P.¹ 

[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AZ, England

关键词: Epoxidation;    Asymmetric;    Ketone;    Dioxirane;   

DOI  :  10.1016/j.tet.2010.04.004

来源: Elsevier

【 摘 要 】

A general synthetic route allowing access to several spirocyclic N-carbethoxy-azabicyclo[3.2.1]octanones is developed. These novel ketones efficiently catalyse alkene epoxidation using Oxone (R) with up to 91.5% ee. (C) 2010 Elsevier Ltd. All rights reserved.

【 授权许可】

Free