期刊论文详细信息
TETRAHEDRON 卷:74
Selective formation of heteroaryl thioethers via a phosphonium ion coupling reaction
Article
Anderson, Ryan G.1  Jett, Brianna M.1  McNally, Andrew1 
[1] Colorado State Univ, Dept Chem, Ft Collins, CO 80523 USA
关键词: Pyridines;    Diazines;    C-S bonds;    Heteroaryl thioethers;    Phosphonium salts;    Late-stage functionalization;   
DOI  :  10.1016/j.tet.2017.12.040
来源: Elsevier
PDF
【 摘 要 】

Heteroaryl thioethers, comprised of pyridines and diazines, are an important class of compounds with relevance to medicinal chemistry. Metal-catalyzed cross-couplings and SNAr reactions are traditionally used to form C-S bonds in these systems but are limited by available halogenated precursors. An alternative approach is presented where pyridines and diazines are transformed into heterocyclic phosphonium salts and then C-S bonds are formed by adding thiolate nucleophiles. The process is 4-selective for pyridines, simple to execute and can be used to make derivatives of complex pharmaceuticals. (C) 2017 Elsevier Ltd. All rights reserved.

【 授权许可】

Free   

【 预 览 】
附件列表
Files Size Format View
10_1016_j_tet_2017_12_040.pdf 659KB PDF download
  文献评价指标  
  下载次数:3次 浏览次数:1次