Fabrication of a nanostructure-based electrochemical sensor for simultaneous determination of N-acetylcysteine and acetaminophen

TALANTA

卷:85

Article

Beitollahi, Hadi¹  Raoof, Jahan-Bakhsh²  Hosseinzadeh, Rahman³ 

[1] Int Ctr Sci High Technol & Environm Sci, Dept Environm, Res Inst Environm Sci, Kerman, Iran

[2] Univ Mazandaran, Electroanalyt Chem Res Lab, Dept Analyt Chem, Fac Chem, Babol Sar, Iran

[3] Univ Mazandaran, Dept Organ Chem, Fac Chem, Babol Sar, Iran

关键词: N-acetylcysteine;    Acetaminophen;    Carbon nanotubes;    Modified carbon paste electrode;    Voltammetry;   

DOI  :  10.1016/j.talanta.2011.07.054

来源: Elsevier

【 摘 要 】

A carbon-paste electrode modified with 2,7-bis(ferrocenyl ethyl)fluoren-9-one (2,7-BF) and carbon nanotubes (CNTs) was used for the sensitive and selective voltammetric determination of N-acetylcysteine (NAC). The mediated oxidation of NAC at the modified electrode was investigated by cyclic voltammetry (CV). Also, the values of catalytic rate constant (k), and diffusion coefficient (D) for NAC were calculated. Differential pulse voltammetry (DPV) of NAC at the modified electrode exhibited two linear dynamic ranges with a detection limit (3 sigma) of 52.0 nmol L-1. DPV was used for simultaneous determination of NAC and acetaminophen (AC) at the modified electrode, and quantitation of NAC and AC in some real samples by the standard addition method. (C) 2011 Elsevier B.V. All rights reserved.

【 授权许可】

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