Development of a multiresidue method for the determination of endocrine disrupters in fish fillet using gas chromatography-triple quadrupole tandem mass spectrometry

TALANTA

卷:116

Article

Munaretto, Juliana S.¹  Ferronato, Giovana¹  Ribeiro, Lucila C.¹  Martins, Manoel L.¹  Adaime, Martha B.¹  Zanella, Renato¹ 

[1] Univ Fed Santa Maria, Lab Pesticide Residue Anal LARP, Dept Chem, BR-97105900 Santa Maria, RS, Brazil

关键词: GC-MS/MS;    QuEChERS;    Endocrine disrupters;    Fish fillet;   

DOI  :  10.1016/j.talanta.2013.07.047

来源: Elsevier

【 摘 要 】

Endocrine Disrupter Compounds (EDCs) are responsible for alterations in the endocrine system functions. Aquatic organisms are able to accumulate EDCs residues, being the major source of contamination for top predators and human consumers. This study aimed to develop and validate a method for the determination of 40 EDCs in fish fillet using modified QuEChERS and Gas Chromatography coupled with Mass Spectrometry in tandem (GC-MS/MS). A factorial design was used to optimize the extraction procedure. Method validation presented recoveries from 70.1% to 120.0% with RSD <20% and method limit of detection ranged from 03 to 7.5 mu g kg(-1), showing good accuracy and precision. This method was successfully applied to the analysis of fish fillet from different species and residues of bisphenol A, chlorpyrifos and bifenthrin were detected. The proposed method proved to be effective for the determination of EDCs in fish fillet at very low concentration levels. (C) 2013 Elsevier B.V. All rights reserved.

【 授权许可】

Free