期刊论文详细信息
TALANTA 卷:207
Biosensing of D-dimer, making the transition from the central hospital laboratory to bedside determination
Article
Tasic, Nikola1  Paixao, Thiago R. L. C.1  Goncalves, Luis Moreira1 
[1] Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, Ave Prof Lineu Prestes 748, Sao Paulo, SP, Brazil
关键词: Biomarker;    Clinical chemistry;    Diagnosis and prognosis;    Emergency medicine;    Hematology;    Point-of-care or point-of-need sensing;   
DOI  :  10.1016/j.talanta.2019.120270
来源: Elsevier
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【 摘 要 】

Since the disclosure of the fibrinogen degradation mechanism, around half a century ago, a significant number of papers have been published related to the clinical relevance of D-dimer, a molecule immune to additional enzymatic decomposition by plasmin. Due to the obliquity of regulating blood coagulation in pathological events, the number of diseases and conditions associated with abnormal levels of D-dimer includes deep vein thrombosis, pulmonary embolism, sepsis, myocardial infarction, disseminated intravascular coagulation, among many others. D-dimer not only is an important player in medical diagnosis but also its role as a prognosis biomarker is being revealed. However, the number of analytical alternative methods has not accompanied this trend, even though novel simple point-of-care devices would certainly boost the relevance of D-dimer in emergency medicine. Some reasons for that could be related to the fact that D-dimer is a challenging analyte present in complex samples like blood. In this manuscript, subsequent to a fibrinogen degradation process introduction, it is provided a historical overview of the early D-dimer assays, followed by an extended focus on innovative solutions, with a spotlight on the electrochemical bioanalytical devices. The discussion is accompanied with a critical analysis and concluding thoughts concerning future perspectives.

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