Nanomaterial labels in electrochemical immunosensors and immunoassays

TALANTA

卷:74

Review

Liu, Guodong¹  Lin, Yuehe² 

[1] N Dakota State Univ, Dept Chem & Mol Biol, Fargo, ND 58105 USA

[2] Pacific NW Natl Lab, Richland, WA 99352 USA

关键词: nanomaterials;    nanoparticles;    immunosensors;    immunoassays;    carbon nanotubes;    biomarkers;   

DOI  :  10.1016/j.talanta.2007.10.014

来源: Elsevier

【 摘 要 】

This article reviews recent advances in nanomaterial labels in electrochemical immunosensors and immunoassays. Various nanomaterial labels are discussed, including colloidal gold/silver, semiconductor nanoparticles, and markers loaded nanocarriers (carbon nanotubes, apoferritin, silica nanoparticles, and liposome beads). The enormous signal enhancement associated with the use of nanomaterial labels and with the formation of nanomaterial-antibody-antigen assemblies provides the basis for ultrasensitive electrochemical detection of disease-related protein biomarkers, biothreat agents, or infectious agents. In general, all endeavors cited here are geared to achieve one or more of the following goals: signal amplification by several orders of magnitude, lower detection limits, and detecting multiple targets. (c) 2007 Elsevier B.V. All rights reserved.

【 授权许可】

Free