A bis(pyridine-2-ylmethyl)amine-based selective and sensitive colorimetric and fluorescent chemosensor for Cu2+

SENSORS AND ACTUATORS B-CHEMICAL

卷:222

Article

Zheng, Xu¹  Lee, Kum Hee¹  Liu, Hongguang¹  Park, So-Young¹  Yoon, Seung Soo¹  Lee, Jin Yong¹  Kim, Yang-Gyun¹ 

[1] Sungkyunkwan Univ, Dept Chem, Suwon 440746, South Korea

关键词: Colorimetric;    Fluorescent;    Cu2+;    DPA;    Chemosensor;   

DOI  :  10.1016/j.snb.2015.08.053

来源: Elsevier

【 摘 要 】

A new bis(pyridine-2-ylmethyl)amine derivative (1) was synthesized as a colorimetric and fluorescent chemosensor for metal ions. Experimental results indicate that I displays significant colorimetric and fluorescent changes upon binding of Cu2+. Since 1 has a high water solubility as well as good cell-permeability, it successfully applied to detect the presence of Cu2+ ion in HepG2 cells in culture medium. Thus, 1 can be used as a potential Cu2+ chemosensor in aqueous solution and mammalian cells. Further, the fluorescence behavior of 1 upon Cu2+ binding was well explained by our quantum calculation based on electronic structure. (C) 2015 Elsevier B.V. All rights reserved.

【 授权许可】

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