A unique turn-off fluorescent strategy for sensing dopamine based on formed polydopamine (pDA) using graphene quantum dots (GQDs) as fluorescent probe

SENSORS AND ACTUATORS B-CHEMICAL

卷:221

Article

Weng, Shaohuang¹  Liang, Dong³  Qiu, Huazhang¹  Liu, Zongen¹  Lin, Zhen¹  Zheng, Zongfu^2,4  Liu, Ailin¹  Chen, Wei¹  Lin, Xinhua^1,3 

[1] Fujian Med Univ, Dept Pharmaceut Anal, Higher Educ Key Lab Nano Biomed Technol Fujian Pr, Fac Pharm, Fuzhou 350108, Peoples R China

[2] 476 Hosp PLA, Fuzhou 350002, Peoples R China

[3] Fujian Med Univ, Sch Publ Hlth, Dept Hlth Management, Fuzhou 350108, Peoples R China

[4] Xiamen Univ, Affiliated Dongfang Hosp, Fuzhou 350025, Peoples R China

关键词: Dopamine detection;    Graphene quantum dots;    Fluorescent sensor;    Polydopamine;    Serum;   

DOI  :  10.1016/j.snb.2015.06.093

来源: Elsevier

【 摘 要 】

A rapid, facile fluorescence sensing strategy was developed for dopamine (DA) detection based on poly-dopamine (pDA) formed on the surface of graphene quantum dots (GQDs). The prepared GQDs were strongly luminescent because of the aromatic planar structure. DA could self-polymerize to pDA and snap to the surface of GQDs to form a thin film in alkaline environment, leading to quenching of fluorescence due to fluorescence resonance energy transfer (FRET). With the optimized conditions, the analytical performance illustrated high sensitivity, selectivity in a wide linear range with a detection limit of 8 nM. In addition, the unique method was successfully applied for DA injection test with satisfactory labeled amount. Finally, the proposed strategy was applied for DA detection in serum, wherein accurate results were obtained. (C) 2015 Elsevier B.V. All rights reserved.

【 授权许可】

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