High-sensitivity Sagnac-interferometer biosensor based on exposed core microstructured optical fiber

SENSORS AND ACTUATORS B-CHEMICAL

卷:269

Article

Li, Xuegang^1,2,3  Nguyen, Linh V.^1,2,5  Zhao, Yong³  Ebendorff-Heidepriem, Heike^1,2,4  Warren-Smith, Stephen C.^1,2,4 

[1] Univ Adelaide, IPAS, Adelaide, SA 5005, Australia

[2] Univ Adelaide, Sch Phys Sci, Adelaide, SA 5005, Australia

[3] Northeastern Univ, Coll Informat Sci & Engn, Shenyang 110819, Liaoning, Peoples R China

[4] Univ Adelaide, ARC Ctr Excellence Nanoscale BioPhoton CNBP, Adelaide, SA 5005, Australia

[5] Plant Biosecur Cooperat Res Ctr, Canberra, ACT 2617, Australia

关键词: Biosensor;    Sagnac-interferometer;    Refractive index measurement;    Exposed-core microstructured optical fiber;   

DOI  :  10.1016/j.snb.2018.04.165

来源: Elsevier

【 摘 要 】

A novel, high sensitivity Sagnac-interferometer biosensor based on exposed core microstructured optical fiber (ECF) has been designed and implemented in this paper. The exposed core fiber has noncircular symmetry and thus exhibits birefringence and can form a sensing element within a Sagnac loop interferometer. The exposed-core fiber design provides direct access to the evanescent field, allowing the measurement of bulk refractive index (RI) with a sensitivity of up to -3137 nm/RIU while maintaining the fiber's robustness. The sensor can also detect the localized refractive index changes at the fiber core's surface as the result of a biological binding event. We demonstrate the use of this sensor for label-free sensing of biological molecules by immobilizing biotin onto the fiber core as the probe to capture the target molecule streptavidin. (C) 2018 Elsevier B.V. All rights reserved.

【 授权许可】

Free