Osborn waves following out-of-hospital cardiac arrest-Effect of level of temperature management and risk of arrhythmia and death

RESUSCITATION

卷:128

Article

Hadziselimovic, Edina¹  Thomsen, Jakob Hartvig¹  Kjaergaard, Jesper¹  Kober, Lars¹  Graff, Claus²  Pehrson, Steen¹  Nielsen, Niklas³  Erlinge, David⁴  Frydland, Martin¹  Wiberg, Sebastian¹  Hassager, Christian¹ 

[1] Copenhagen Univ Hosp, Rigshosp, Heart Ctr, Dept Cardiol, Copenhagen, Denmark

[2] Aalborg Univ, Dept Hlth Sci & Technol, Aalborg, Denmark

[3] Helsingborg Hosp, Dept Anesthesia & Intens Care, Helsingborg, Sweden

[4] Lund Univ Hosp, Dept Cardiol, Lund, Sweden

关键词: Cardiac arrest;    Hypothermia;    Repolarization;    Ventricular arrhythmia;    Cardiac arrhythmia;    Osborn waves;    J-waves;    Out-of-hospital cardiac arrest;    Targeted temperature management;    Therapeutic hypothermia;    TTM;   

DOI  :  10.1016/j.resuscitation.2018.04.037

来源: Elsevier

【 摘 要 】

Background: The Osborn or J-wave, an upright deflection of the J-point on the electrocardiogram (ECG), is often observed during severe hypothermia. A possible relation between Osborn waves (OW) and increased risk of ventricular arrhythmia has been reported. We sought to determine whether the level of targeted temperature management (TTM) following out-of-hospital cardiac arrest (OHCA) affects the prevalence of OW and to assess the associations between OW and risk of ventricular arrhythmia and death. Methods and results: The present study is part of the TTM-trial ECG-substudy (including OHCA-patients randomized to TTM at 33 degrees C vs. 36 degrees C from 24 of 36 sites). Serial 12-lead ECGs from 680 (94%) patients were analysed and stratified by OW at predefined time-points (0, 4, 28, 36, 72-h after admission). On admission, the overall prevalence of OW was 16%, increasing to 32% at target temperature, with higher prevalence in the 33 degrees C-group (40% vs. 23%, p < 0.0001). No difference in prevalence was found between the 33 degrees C- and 36 degrees C-groups on admission (18% vs. 14%, p = .11) or after rewarming (13% vs. 10%, p = .44). OW were not associated with increased risk of ventricular arrhythmia (Odds ratio = 0.78 (0.51-1.20), p = .26), but associated with significantly lower 180-day mortality as compared to no OW (38% vs. 52%, p(log-rank) = 0.001) in univariable analyses only. Conclusion: OW are frequent during TTM, particularly in patients treated with 33 degrees C. OW are not associated with increased risk of ventricular arrhythmia, and may be considered a benign physiological phenomenon, associated with lower mortality in univariable analyses.

【 授权许可】

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