Determinants of occurrence and survival after sudden cardiac arrest-A European perspective: The ESCAPE-NET project

RESUSCITATION

卷:124

Article

Empana, Jean-Philippe¹  Blom, Marieke T.²  Boettiger, Bernd W.^3,17  Dagres, Nikolaos⁴  Dekker, Jacqueline M.⁵  Gislason, Gunnar^6,7  Jouven, Xavier¹  Meitinger, Thomas⁸  Ristagno, Giuseppe^9,10  Schwartz, Peter J.¹¹  Jonsson, Martin¹²  Tfelt-Hansen, Jacob^14,15,16  Truhlar, Anatolij¹³  Tan, Hanno L.² 

[1] Univ Paris 05, Paris Cardiovasc Res Ctr, INSERM UMRS 970, Paris, France

[2] Acad Med Ctr, Dept Cardiol, Heart Ctr, Amsterdam, Netherlands

[3] European Resuscitat Council, Brussels, Belgium

[4] European Heart Rhythm Assoc, Sophia Antipolis, France

[5] Vrije Univ Amsterdam Med Ctr, Amsterdam, Netherlands

[6] Copenhagen Univ Hosp, Dept Cardiol, Gentofte, Denmark

[7] Danish Heart Fdn, Copenhagen, Denmark

[8] Helmholtz Ctr, Dept Human Genet, Munich, Germany

[9] IRCCS, Ist Ric Farmacol Mario Negri, Milan, Italy

[10] Italian Resuscitat Council, Bologna, Italy

[11] IRCCS, Ist Auxol Italiano, Reference Network Rare & Low Prevalence Complexe, Milan, Italy

[12] Karolinska Inst, Ctr Resuscitat Sci, Dept Med, Stockholm, Sweden

[13] Emergency Med Serv Hradec Kralove Reg, Hradec Kralove, Czech Republic

[14] Copenhagen Univ Hosp, Dept Cardiol, Heart Ctr, Rigshosp, Copenhagen, Denmark

[15] Univ Copenhagen, Dept Forens Med, Fac Med Sci, Copenhagen, Denmark

[16] Reference Network Rare & Low Prevalence Complexe, Milan, Italy

[17] Univ Hosp Cologne, Dept Anesthesiol & Intens Care Med, Cologne, Germany

关键词: Sudden cardiac arrest;    Resuscitation;    Automated external defibrillator;    Genetics;   

DOI  :  10.1016/j.resuscitation.2017.12.011

来源: Elsevier

【 摘 要 】

Aims: The ESCAPE-NET project (European Sudden Cardiac Arrest network-towards Prevention, Education and New Effective Treatments) aims to study: (1) risk factors and mechanisms for the occurrence of sudden cardiac arrest (SCA) in the population, and (2) risk factors and treatment strategies for survival after SCA on a European scale. Methods: This is an Horizon2020 funded program of the European Union, performed by a European public-private consortium of 16 partners across 10 EU countries. There are 11 deep-phenotyped SCA cohorts for the study of risk factors and treatment strategies for survival after SCA, and 5 deep-phenotyped observational prospective population cohorts for the study of risk factors for occurrence of SCA. Personalized risk scores for predicting SCA onset and for predicting survival after SCA will be derived and validated. Results: The 11 clinical studies with SCA cases comprise 85,790 SCA cases; the 5 observational prospective population cohorts include 53,060 subjects. A total of 15,000 SCA samples will be genotyped for common and rare variants at the Helmholtz Zentrum Munchen (Germany) using the Illumina Global Screening Array which contains > 770,000 SNPs, and after imputation, a database of an estimated > 9 million variants will be available for genome wide association studies. Standardization of risk factors definition and outcomes is ongoing. An Executive Committee has been created along with a Collaboration Policy document. Conclusion: ESCAPE-NET will complement ongoing efforts on SCA outside Europe and within Europe including the EuReCa project. (c) 2017 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY license.

【 授权许可】

Free