Long-term survival and health-related quality of life after in-hospital cardiac arrest

RESUSCITATION

卷:167

Article

Schluep, Marc^1,4  Hoeks, Sanne Elisabeth¹  Blans, Michiel³  van den Bogaard, Bas⁴  Koopman-van Gemert, Ankie⁵  Kuijs, Cees⁶  Hukshorn, Chris⁷  van der Meer, Nardo⁸  Knook, Marco⁹  van Melsen, Trudy¹⁰  Peters, Rene¹¹  Perik, Patrick¹²  Simons, Koen¹³  Spijkers, Gerben¹⁴  Vermeijden, Wytze¹⁵  Wils, Evert-Jan¹⁶  Stolker, R. J. (Robert Jan)¹  Endeman, H. (Rik)² 

[1] Erasmus MC, Dept Anaesthesiol, Rotterdam, Netherlands

[2] Erasmus MC, Dept Intens Care Med, Rotterdam, Netherlands

[3] Rijnstate Hosp, Dept Intens Care Med, Arnhem, Netherlands

[4] OLVG, Dept Intens Care Med, Amsterdam, Netherlands

[5] Albert Schweitzer Hosp, Dept Anaesthesiol, Dordrecht, Netherlands

[6] Maasstad Hosp, Resuscitat Comm, Rotterdam, Netherlands

[7] Isala Hosp, Dept Intens Care Med, Zwolle, Netherlands

[8] Amphia Hosp, Dept Intens Care Med, Bred, Netherlands

[9] Reinier de Graaf Gasthuis, Dept Intens Care Med, Delft, Netherlands

[10] Haaglanden Med Ctr, Dept Intens Care Med, The Hague, Netherlands

[11] Tergooi Hosp, Dept Cardiol, Hilversum, Netherlands

[12] Deventer Hosp, Dept Cardiol, Deventer, Netherlands

[13] Jeroen Bosch Hosp, Dept Intens Care Med, Shertogenbosch, Netherlands

[14] ZorgSaam Zeeuws Vlaanderen, Dept Hosp Med, Terneuzen, Netherlands

[15] Med Spectrum Twente, Dept Intens Care Med, Enschede, Netherlands

[16] Franciscus Gasthuis & Vlietland, Dept Intens Care Med, Rotterdam, Netherlands

关键词: In hospital cardiac arrest;    Outcome;    Long-term survival;    Health-related quality of life;    IHCA;    HRQoL;    Prognostication;   

DOI  :  10.1016/j.resuscitation.2021.07.006

来源: Elsevier

【 摘 要 】

Introduction: In-hospital cardiac arrest (IHCA) is an adverse event associated with high mortality. Because of the impact of IHCA more data is needed on incidence, outcomes and associated factors that are present prior to cardiac arrest. The aim was to assess one-year survival, patient-centred outcomes after IHCA and their associated pre-arrest factors. Methods: A multicentre prospective cohort study in 25 hospitals between January 1st 2017 and May 31st 2018. Patients > 18 years receiving car-diopulmonary resuscitation (CPR) for IHCA were included. Data were collected using Utstein and COSCA-criteria, supplemented by pre-arrest Mod-ified Rankin Scale (MRS, functional status) and morbidity through the Charlson Comorbidity Index (CCI). Main outcomes were survival, health-related quality of life (HRQoL, EuroQoL) and functional status (MRS) after one-year. Results: A total of 713 patients were included, 64.5% was male, median age was 63 years (IQR 52-72) and 72.8% had a non-shockable rhythm, 394 (55.3%) achieved ROSC, 231 (32.4%) survived to hospital discharge and 198 (27.8%) survived one year after cardiac arrest. Higher pre-arrest MRS, age and CCI were associated with mortality. At one year, patients rated HRQoL 72/100 points on the EQ-VAS and 69.7% was functionally independent. Conclusion: One-year survival after IHCA in this study is 27.8%, which is relatively high compared to previous studies. Survival is associated with a patient's pre-arrest functional status and morbidity. HRQoL appears acceptable, however functional rehabilitation warrants attention. These findings provide a comprehensive insight in in-hospital cardiac arrest prognosis.

【 授权许可】

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