Pharmacokinetics of intraosseous and central venous drug delivery during cardiopulmonary resuscitation

RESUSCITATION

卷:83

Article

Hoskins, Stephen L.¹  do Nascimento, Paulo, Jr.^1,2  Lima, Rodrigo M.^1,2  Espana-Tenorio, Jonathan M.¹  Kramer, George C.¹ 

[1] Univ Texas Med Branch, Dept Anaesthesiol, Resuscitat Res Lab, Galveston, TX 77555 USA

[2] UNESP, Dept Anesthesiol, Sao Paulo Med Sch, Botucatu, SP, Brazil

关键词: Intraosseous;    Cardiopulmonary resuscitation;    CPR;    Pharmacokinetics;    Tracers;    Drug delivery;   

DOI  :  10.1016/j.resuscitation.2011.07.041

来源: Elsevier

【 摘 要 】

We compared the pharmacokinetics of intraosseous (IO) drug delivery via tibia or sternum, with central venous (CV) drug delivery during cardiopulmonary resuscitation (CPR). Methods: CPR of anesthetized KCl arrest swine was initiated 8 min post arrest. Evans blue and indocyanine green, each were simultaneously injected as a bolus with adrenaline through IO sternal and tibial needles, respectively, n = 7. In second group (n = 6) simultaneous IO sternal and IV central venous (CV) injections were made. Results: Peak arterial blood concentrations were achieved faster for sternal IO vs. tibial IO administration (53 +/- 11 s vs. 107 +/- 27 s, p = 0.03). Tibial IO dose delivered was 65% of sternal administration (p = 0.003). Time to peak blood concentration was similar for sternal IO and CV administration (97 +/- 17 s vs. 70 +/- 12 s, respectively; p = 0.17) with total dose delivered of sternal being 86% of the dose delivered via CV (p = 0.22). Conclusions: IO drug administrations via either the sternum or tibia were effective during CPR in anesthetized swine. However, IO drug administration via the sternum was significantly faster and delivered a larger dose. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

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