Epstein-Barr virus (EBV)-encoded dUTPase and chronic restraint induce impaired learning and memory and sickness responses

PHYSIOLOGY & BEHAVIOR

卷:137

Article

Aubrecht, Taryn G.¹  Weil, Zachary M.¹  Ariza, Maria Eugenia²  Williams, Marshall²  Reader, Brenda F.³  Glaser, Ronald^2,3  Sheridan, John F.^3,4  Nelson, Randy J.¹ 

[1] Ohio State Univ, Dept Neurosci, Wexner Med Ctr, Columbus, OH 43210 USA

[2] Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA

[3] Ohio State Univ, Ctr Comprehens Canc, Wexner Med Ctr, Inst Behav Med Res, Columbus, OH 43210 USA

[4] Ohio State Univ, Div Biosci, Coll Dent, Columbus, OH 43210 USA

关键词: Epstein-Barr virus;    Chronic restraint stress;    Sickness response;    Learning and memory;   

DOI  :  10.1016/j.physbeh.2014.07.001

来源: Elsevier

【 摘 要 】

Most adult humans have been infected with Epstein-Barr virus (EBV) and carry the latent virus.The EBV genome codes for several proteins that form an early antigen complex important for viral replication; one of these proteins is deoxyuridine triphosphate nucleotidohydrolase (dUTPase). The EBV-encoded dUTPase can induce sickness responses in mice. Because stress can increase latent virus reactivation, we hypothesized that chronic restraint would exacerbate sickness behaviors elicited by EBV-encoded dUTPase. Male Swiss-Webster mice were injected daily for 15 days with either saline or EBV-encoded dUTPase. Additionally, half of the mice from each condition were either restrained for 3 h daily or left undisturbed. Restraint stress impaired learning and memory in the passive avoidance chamber; impaired learning and memory was due to EBV-encoded dUTPase injected into restrained mice. EBV-encoded dUTPase induced sickness responses and restraint stress interacts with EBV-encoded dUTPase to exacerbate the sickness response. These data support a role for EBV-encoded dUTPase and restraint stress in altering the pathophysiology of EBV independent of viral replication. (C) 2014 Elsevier Inc All rights reserved.

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