Maternal feeding associated to post-weaning diet affects metabolic and behavioral parameters in female offspring

PHYSIOLOGY & BEHAVIOR

卷:204

Article

Fisch, Joana¹  Feistauer, Vanessa²  de Moura, Ana Carolina²  Silva, Andrew Oliveira³  Bollis, Vanessa⁴  Porawski, Marilene²  Almeida, Silvana^1,2  Guedes, Renata Padilha^1,2  Barschak, Alethea Gatto^1,3  Giovenardi, Marcia^1,2 

[1] UFCSPA, Programa Posgrad Ciencias Saude, Rua Sarmento Leite 245, BR-90050170 Porto Alegre, RS, Brazil

[2] UFCSPA, Programa Posgrad Biociencias, Rua Sarmento Leite 245, BR-90050170 Porto Alegre, RS, Brazil

[3] UFCSPA, Programa Posgrad Patol, Rua Sarmento Leite 245, BR-90050170 Porto Alegre, RS, Brazil

[4] UFCSPA, Curso Biomed, Rua Sarmento Leite 245, BR-90050170 Porto Alegre, RS, Brazil

关键词: Leptin;    Insulin;    Adipose tissue;    Open field test;    Caloric restriction;    Hypercaloric diet;   

DOI  :  10.1016/j.physbeh.2019.02.026

来源: Elsevier

【 摘 要 】

Genetic and environmental factors related to maternal diet may predispose offspring to serious diseases. However, consequences of a maternal diet intervention during gestation and lactation, and its association with caloric restriction after weaning on the progeny are not completely known. In this context, the goal of the present study was to investigate how different maternal diets, control (CONT), hypercaloric (HD) or restrictive (RD) diets during gestation and lactation, may affect the metabolism and behavior of the offspring that was also submitted to RD. Experimental groups were abbreviated accordingly maternal/offspring diets: CONT/CONT, CONT/RD, RD/CONT, RD/RD, HD/CONT, HD/RD. Our results showed that glucose serum concentration is increased in mice from dams fed a HD. However, offspring from RD-fed dams showed lower insulin and leptin levels than the other groups, indicating a maternal diet effect. Moreover, animals from RD/CONT group showed a higher adipocyte area in comparison to both HD/CONT and CON/CONT. Offspring from RD-fed dams exhibited a decrease in lateral area locomotion in the open field test. Evaluation of anxiety-like behavior and recognition memory showed no significant difference among groups. Thus, maternal RD provides a beneficial response in metabolic parameters, but its effects on behavior is not completely clarified.

【 授权许可】

Free