Effect of Different Starvation Levels on Cognitive Ability in Mice

5th Annual International Conference on Material Science and Environmental Engineering

材料科学;生态环境科学

Li, Xiaobing^1,2 ; Zhi, Guoguo^2 ; Yu, Yi^2 ; Cai, Lingyu^2 ; Li, Peng^2 ; Zhang, Danhua^2 ; Bao, Shuting^2 ; Hu, Wenlong^2 ; Shen, Haiyan^2 ; Song, Fujuan^2

School of Basic Medical, Henan University of Chinese Medicine, Zhengzhou, China^1

First School of Clinical Medicine, Henan University of Chinese Medicine, Zhengzhou, China^2

关键词: Catalase activity;    Cognitive ability;    Feeding amount;    Four-group;    Morris water maze;    Open field test;    Surrounding environment;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/301/1/012022/pdf
DOI  :  10.1088/1757-899X/301/1/012022

来源: IOP

【 摘 要 】

Objective: To study the effect of different starvation levels on cognitive ability in mice. Method: Mice were randomly divided into four groups: normal group, dieting group A, dieting group B, dieting group C. The mice of normal group were given normal feeding amount, the rest of groups were given 3/4 of normal feeding amount, 2/4 of normal feeding amount and 1/4 of normal feeding amount. After feeding mice four days, the weight was observed and T-maze experiment, Morris water maze test, open field test and Serum Catalase activity were detected. Result: Compared with the normal group, the correct rate of the intervention group in the T-maze experiment was decreased and dieting group A> dieting group B> dieting group C. In the Morris water maze test, Compared with the normal group, the correct rate of the intervention group was increased. Among these three intervention groups, dieting group A had the highest correct rate and the difference of dieting group B and dieting group C were similar. In the open field test, Compared with the normal group, the exploration rate of the surrounding environment in the intervention group was increased. In the Serum Catalase test, Compared with the normal group, the activities of serum peroxidase in the intervention groups were decreased and dieting group A> dieting group B> dieting group C. Conclusion: A certain level of starvation could affect the cognitive ability of mice. In a certain range, the level of starvation is inversely proportional to cognitive ability in mice.