Obesity surgery and gut-brain communication

PHYSIOLOGY & BEHAVIOR

卷:105

Article

Berthoud, Hans-Rudolf¹  Shin, Andrew C.¹  Zheng, Huiyuan¹ 

[1] Louisiana State Univ Syst, Pennington Biomed Res Ctr, Neurobiol Nutr Lab, Baton Rouge, LA 70808 USA

关键词: Bariatric surgery;    Roux-en-Y gastric bypass;    Metabolic syndrome;    Type-2 diabetes;    GLP-1;    PYY;    Ghrelin;    Insulin;    Amylin;    Vagus nerve;    Energy homeostasis;    Satiation;    Glucose homeostasis;   

DOI  :  10.1016/j.physbeh.2011.01.023

来源: Elsevier

【 摘 要 】

The prevalence of obesity, and the cluster of serious metabolic diseases it is associated with, continues to rise globally, and hopes for effective treatment with drugs have been considerably set back. Thus, success with bariatric surgeries to induce sustained body weight loss and effectively cure most of the associated comorbidities appears almost miraculous and systematic investigation of the mechanisms at work has gained momentum. Here, we will discuss the basic organization of gut-brain communication and review clinical and pre-clinical investigations on the potential mechanisms by which gastric bypass surgery leads to its beneficial effects on energy balance and glucose homeostasis. Although a lot has been learned regarding changes in energy intake and expenditure, secretion of gut hormones, and improvement in glucose homeostasis, there has not yet been the breakthrough observation of identifying a key signaling component common to the beneficial effects of the surgery. However, given the complexity and redundancy of gut-brain signaling and gut signaling to other relevant organs, it is perhaps more realistic to expect a number of key signaling changes that act in concert to bring about the miracle. (C) 2011 Elsevier Inc. All rights reserved.

【 授权许可】

Free