Differences in fatigue-like behavior in the lipopolysaccharide and poly I:C inflammatory animal models

PHYSIOLOGY & BEHAVIOR

卷:232

Article

Foster, Catherine G.¹  Landowski, Lila M.¹  Sutherland, Brad A.¹  Howells, David W.¹ 

[1] Univ Tasmania, Coll Hlth & Med, Tasmanian Sch Med, Hobart, Tas, Australia

关键词: Animal models;    Inflammation;    Behavior;    Fatigue;    LPS;    Poly I:C;   

DOI  :  10.1016/j.physbeh.2021.113347

来源: Elsevier

【 摘 要 】

Central fatigue is a condition associated with impairment of the central nervous system often leading to the manifestation of a range of debilitating symptoms. Fatigue can be a consequence of systemic inflammation following an infection. Administration of lipopolysaccharide (LPS) and polyriboinosinic:polyribocytidlic (poly I: C) to animals can induce systemic inflammation by mimicking a bacterial or viral infection respectively and therefore have been used as models of fatigue. We evaluated a range of phenotypic behaviors exhibited in the LPS and poly I:C animal models to assess whether they adequately replicate fatigue symptomology in humans. In addition to standard observation- and intervention-based behavioral assessments, we used powerful in-cage monitoring technology to quantify rodent behavior without external interference. LPS and poly I:C treated Sprague Hawley rats displayed 'sickness behaviors' of elevated temperature, weight loss and reduced activity in the open field test and with in-cage monitoring within 24 h post-treatment, but only LPS-treated rats displayed these behaviors beyond these acute time-points. Once sickness behavior diminished, LPS-treated rats exhibited an increase in reward-seeking and motivation behaviors. Overall, these results suggest that the LPS animal model produces an extensive and sustained fatigue-like phenotype, whereas the poly I:C model only produced acute effects. Our results suggest that the LPS animal model is a more suitable candidate for further studies on central fatigue-like behavior.

【 授权许可】

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