Cannabinoid receptor agonism suppresses tremor, cognition disturbances and anxiety-like behaviors in a rat model of essential tremor

PHYSIOLOGY & BEHAVIOR

卷:164

Article

Abbassian, Hassan¹  Esmaeili, Parisa²  Tahamtan, Mahshid¹  Aghaei, Iraj^3,4  Vaziri, Zohreh¹  Sheibani, Vahid¹  Whalley, Benjamin J.⁵  Shabani, Mohammad¹ 

[1] Kerman Univ Med Sci, Neuropharmacol Inst, Neurosci Res Ctr, Kerman 7619813159, Iran

[2] Tarbiat Modares Univ, Dept Physiol, Fac Med Sci, Tehran, Iran

[3] Guilan Univ Med Sci, Cellular & Mol Res Ctr, Rasht, Iran

[4] Guilan Univ Med Sci, Dept Nursing, Rasht, Iran

[5] Univ Reading, Sch Chem Food & Nutr Sci & Pharm, Dept Pharm, Reading RG6 6AP, Berks, England

关键词: WIN55, 212-2;    Harmaline;    CB agonism;    Tremor;    Memory;   

DOI  :  10.1016/j.physbeh.2016.06.013

来源: Elsevier

【 摘 要 】

Cognitive and motor disturbances are serious consequences of tremor induced by motor disorders. Despite a lack of effective clinical treatment, some potential therapeutic agents have been used to alleviate the cognitive symptoms in the animal models of tremor. In the current study, the effects of WIN55, 212-2 (WIN), a cannabinoid receptor (CBR) agonist, on harmaline-induced motor and cognitive impairments were studied. Adult rats were treated with WIN (0.5 mg/kg; i.p.) 15 min before harmaline administration (10 mg/kg; ip) after which exploratory and anxiety related behaviors, and cognitive function were assessed using open-field behavior and shuttle box tests. Rats that received harmaline only exhibited a markedly reduced number of central square entries when compared to harmaline vehicle-treated controls, whereas those treated with WIN and harmaline showed a significant increase in central square entries, compared to harmaline only treated. The passive avoidance memory impairments observed in harmaline treated rats, was reversed somewhat by administration of WIN. The neuroprotective and anxiolytic effects of WIN demonstrated in the current study can be offered cannabinoid receptor (CBR) agonism as a potential neuroprotective agent in the treatment of patients with tremor that manifest mental dysfunctions. (C) 2016 Elsevier Inc All rights reserved.

【 授权许可】

Free