Fatty acid amide supplementation decreases impulsivity in young adult heavy drinkers

PHYSIOLOGY & BEHAVIOR

卷:155

Article

van Kooten, Maria J.^1,2,3  Veldhuizen, Maria G.^1,2  de Araujo, Ivan E.^1,2  O'Malley, Stephanie S.²  Small, Dana M.^1,2,4 

[1] John B Pierce Lab, 290 Congress Ave, New Haven, CT 06519 USA

[2] Yale Univ, Sch Med, Dept Psychiat, 300 George St, New Haven, CT 06511 USA

[3] Univ Groningen, Univ Med Ctr Groningen, Fac Med Sci, Antonius Deusinglaan 1, NL-9713 AV Groningen, Netherlands

[4] Univ Cologne, Albertus Magnus Pl, D-09235 Cologne, Germany

关键词: DEA;    Alcohol;    Impulsivity;    Go/No-Go task;    Inhibitory control;    Dopamine;   

DOI  :  10.1016/j.physbeh.2015.11.032

来源: Elsevier

【 摘 要 】

Compromised dopamine signaling in the striatum has been associated with the expression of impulsive behaviors in addiction, obesity and alcoholism. In rodents, intragastric infusion of the fatty acid amide oleoylethanolamide increases striatal extracellular dopamine levels via vagal afferent signaling. Here we tested whether supplementation with PhosphoLean (TM), a dietary supplement that contains the precursor of the fatty acid amide oleoylethanolamide (N-oleyl-phosphatidylethanolamine), would reduce impulsive responding and alcohol use in heavy drinking young adults. Twenty-two individuals were assigned to a three-week supplementation regimen with PhosphoLean (TM) or placebo. Impulsivity was assessed with self -report questionnaires and behavioral tasks pre- and post-supplementation. Although self-report measures of impulsivity did not change, supplementation with PhosphoLean (TM), but not placebo, significantly reduced false alarm rate on a Go/No-Go task. In addition, an association was found between improved sensitivity on the Go/No-Go task and reduced alcohol intake. These findings provide preliminary evidence that promoting fatty acid derived gut-brain dopamine communication may have therapeutic potential for reducing impulsivity in heavy drinkers. (C) 2015 Elsevier Inc. All rights reserved.

【 授权许可】

Free