Thirst and sodium appetite in rats with experimental nephrotic syndrome

PHYSIOLOGY & BEHAVIOR

卷:149

Article

Xu, Jie¹  Johnson, Alan Kim^1,2,3,4  Thunhorst, Robert L.^1,4 

[1] Univ Iowa, Dept Psychol Brain Sci, Iowa City, IA 52242 USA

[2] Univ Iowa, Dept Hlth & Human Physiol, Iowa City, IA 52242 USA

[3] Univ Iowa, Dept Pharmacol, Iowa City, IA 52242 USA

[4] Univ Iowa, Francois M Abboud Cardiovasc Ctr, Iowa City, IA 52242 USA

关键词: Furosemide;    Captopril;    Isoproterenol;    Angiotensin II;    Plasma renin activity;    Vasopressin;    Aldosterone;    Adriamycin;   

DOI  :  10.1016/j.physbeh.2015.06.032

来源: Elsevier

【 摘 要 】

Nephrotic syndrome is a renal disease accompanied by abnormal body fluid balance. The present experiments investigated the role of behavioral mechanisms in contributing to disordered fluid homeostasis in rats with experimentally-induced nephrotic syndrome. The studies examined water and sodium ingestion under ad libitum conditions and in response to dehydration-related challenges in rats made nephrotic by treatment with the antibiotic, adriamycin. Rats with nephrotic syndrome had greater ad libitum water intakes beginning 3 weeks after treatment, but daily sodium (03 M NaCl) intakes were not affected. Nephrotic rats showed attenuated water and sodium intakes after combined treatment with furosemide (10 mg/kg) and captopril (2 mg/kg), reduced water intakes after 20 h of water deprivation, and diminished water intakes, plasma renin activity and aldosterone secretion after subcutaneous isoproterenol (30 mu g/kg). However, the adriamycin-treated animals had normal water intakes in response to subcutaneous hypertonic saline (4% at 0.75 m1/100 g) and central injections of angiotensin II (10, 20, and 50 ng). The results suggest that water and sodium ingestion in response to hypovolemic/hypotensive stimuli are disturbed in nephrotic rats, and provide evidence that the disordered behaviors reflect disturbances of the peripheral renin-angiotensin-aldosterone system. (C) 2015 Elsevier Inc. All rights reserved.

【 授权许可】

Free