Role of melanin-concentrating hormone in the control of ethanol consumption Region-specific effects revealed by expression and injection studies

PHYSIOLOGY & BEHAVIOR

卷:101

Article

Morganstern, I.¹  Chang, G-Q¹  Chen, Y-W^2,3  Barson, J. R.¹  Zhiyu, Y.¹  Hoebel, B. G.^2,3  Leibowitz, S. F.¹ 

[1] Rockefeller Univ, Lab Behav Neurobiol, New York, NY 10065 USA

[2] Princeton Univ, Dept Psychol, Princeton, NJ 08544 USA

[3] Princeton Univ, Princeton Neurosci Inst, Princeton, NJ 08544 USA

关键词: Melanin concentrating hormone;    Lateral hypothalamus;    Perifornical hypothalamus;    Zona incerta;    Paraventricular nucleus of the hypothalamus;    Nucleus accumbens;    Ethanol;   

DOI  :  10.1016/j.physbeh.2010.07.009

来源: Elsevier

【 摘 要 】

The peptide melanin-concentrating hormone (MCH) produced mainly by cells in the lateral hypothalamus (LH) penfornical area (PF) and zona incerta (ZI) is suggested to have a role in the consumption of rewarding substances such as ethanol sucrose and palatable food However there is limited information on the specific brain sites where MCH acts to stimulate Intake of these rewarding substances and on the feedback effects that their consumption has on the expression of endogenous MCH The current study investigated MCH in relation to ethanol consumption in Sprague-Dawley rats In Experiment 1 chronic consumption of ethanol (from 070 to 2 7 g/kg/day) dose-dependently reduced MCH gene expression in the LH In Experiments 2-4 the opposite effect was observed with acute oral ethanol which stimulated MCH expression specifically in the LH but not the ZI In Experiment 5 the effect of MCH injection in brain-cannulated rats on ethanol consumption was examined Compared to saline MCH injected in the paraventricular nucleus (PVN) and nucleus accumbens (NAc) selectively stimulated ethanol consumption without affecting food or water intake In contrast it reduced ethanol intake when administered into the LH while having no effect in the ZI These results demonstrate that voluntary chronic consumption of ethanol leads to local negative feedback control of MCH expression in the LH However with a brief exposure ethanol stimulates MCH-expressing neurons in this region which through projections to the feeding-related PVN and reward-related NAc can promote further drinking behavior (C) 2010 Elsevier Inc All rights reserved

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