Thirst response to acute hypovolaemia in healthy women and women prone to vasovagal syncope

PHYSIOLOGY & BEHAVIOR

卷:120

Article

Waldreus, Nana^1,2  Hahn, Robert G.^2,3  Engvall, Jan^4,5  Skoog, Johan⁴  Ewerman, Lea⁴  Lindenberger, Marcus^4,6 

[1] Linkoping Univ, Fac Hlth Sci, Dept Social & Welf Studies, Norrkoping, Sweden

[2] Sodertalje Sjukhus, Dept Res, Sodertalje, Sweden

[3] Linkoping Univ, Fac Hlth Sci, Dept Anaesthesiol, S-58585 Linkoping, Sweden

[4] Linkoping Univ, Dept Med & Hlth Sci, S-58585 Linkoping, Sweden

[5] Cty Council Ostergotland, Dept Clin Physiol, Linkoping, Sweden

[6] Cty Council Ostergotland, Dept Cardiol, Linkoping, Sweden

关键词: Thirst;    Angiotensin II;    Hypovolaemia;    Stress;    LBNP;   

DOI  :  10.1016/j.physbeh.2013.06.019

来源: Elsevier

【 摘 要 】

The present study measured self-perceived thirst and plasma angiotensin II (ATII) concentrations during graded hypovolaemic stress, induced by lower body negative pressure (LBNP), to elucidate the dependence of thirst on haemodynamics. A total of 24 women aged between 20 and 36 (mean age, 23) years rated their thirst on a visual analogue scale, graded from 0 to 100, when LBNP of 20,30 and 40 mm Hg was applied. Half of the women had a history of vasovagal syncope (VVS). The results showed that the thirst score increased three-fold when LBNP was applied, from 11 (median; 25th-75th percentiles, 9-25) to 34 (27-53; P < 0.001). The women in the VVS group had twice as great an increase as those without a history of VVS (P < 0.02). The plasma ATII concentration increased significantly in response to LBNP, both in the VVS group and in the control group, but the changes did not correlate with thirst. Application of LBNP decreased systolic and mean arterial pressures, cardiac output and pulse pressure (P < 0.001 for all), but thirst correlated only with increase in heart rate and, independently, with reduction of mean arterial pressure. In conclusion, thirst and ATII increase in response to hypovolaemic stress, but are not statistically related. The haemodynamic parameter that was most strongly related to thirst was tachycardia. (C) 2013 The Authors. Published by Elsevier Inc. All rights reserved.

【 授权许可】

Free