Mapping brain Fos immunoreactivity in response to water deprivation and partial rehydration: Influence of sodium intake

PHYSIOLOGY & BEHAVIOR

卷:151

Article

Dalmasso, Carolina¹  Antunes-Rodrigues, Jose²  Vivas, Laura¹  De Luca, Laurival A., Jr.³ 

[1] Univ Nacl Cordoba, CONICET, Inst Invest Med Mercedes & Martin Ferreyra INIMEC, RA-5000 Cordoba, Argentina

[2] Univ Sao Paulo, Sch Med, Dept Physiol, Sao Paulo, Brazil

[3] Univ Estadual Paulista UNESP, Sch Dent, Dept Physiol & Pathol, Sao Paulo, Brazil

关键词: Thirst;    Sodium appetite;    Water intake;    Angiotensin II;    Reward;    Satiety;   

DOI  :  10.1016/j.physbeh.2015.08.020

来源: Elsevier

【 摘 要 】

Water deprivation (WD) followed by water intake to satiety, produces satiation of thirst and partial rehydration (PR). Thus, WD-PR is a natural method to differentiate thirst from sodium appetite. WD-PR also produces Fos immunoreactivity (Fos-ir) in interconnected areas of a brain circuit postulated to subserve sodium appetite. In the present work, we evaluated the effect of sodium intake on Fos-ir produced by WD-PR in brain areas operationally defined according to the literature as either facilitatory or inhibitory to sodium intake. Isotonic NaCl was available for ingestion in a sodium appetite test performed immediately after a single episode of WD-PR. Sodium intake decreased Fos-ir in facilitatory areas such as the lamina terminalis (particularly subfornical organ and median preoptic nucleus), central amygdala and hypothalamic parvocellular paraventricular nucleus in the forebrain. Sodium intake also decreased Fos-ir in inhibitory areas such as the area postrema, lateral parabrachial nucleus and nucleus of the solitary tract in the hindbrain. In contrast sodium intake further increased Fos-ir that was activated by water deprivation in the dorsal raphe nucleus, another inhibitory area localized in the hindbrain. WD-PR increased Fos-ir in the core and shell of the nucleus accumbens. Sodium intake reduced Fos-ir in both parts of the accumbens. In summary, sodium intake following WD-PR reduced Fos-ir in most facilitatory and inhibitory areas, but increased Fos-ir in another inhibitory area. It also reduced Fos-ir in a reward area (accumbens). The results suggest a functional link between sodium intake and the activity of the hindbrain-forebrain circuitry subserving reward and sodium appetite in response to water deprivation. (C) 2015 Elsevier Inc. All rights reserved.

【 授权许可】

Free