Caffeine - treat or trigger? Disparate behavioral and long-term dopaminergic changes in control and schizophrenia-like Wisket rats

PHYSIOLOGY & BEHAVIOR

卷:236

Article

Horvath, G.¹  Adam, G.⁵  Tuboly, G.⁶  Kekesi, G.¹  Buki, A.¹  Ducza, E.²  Szucs, E.^3,4  Benyhe, S.³  Benedek, G.¹ 

[1] Univ Szeged, Fac Med, Dept Physiol, Om Ter 10, H-6720 Szeged, Hungary

[2] Univ Szeged, Fac Pharm, Dept Pharmacodynam & Biopharm, H-6720 Szeged, Hungary

[3] Hungarian Acad Sci, Biol Res Ctr, Inst Biochem, H-6726 Szeged, Hungary

[4] Univ Szeged, Fac Med, Doctoral Sch Theoret Med, H-6720 Szeged, Hungary

[5] Univ Szeged, Fac Med, Dept Pulmonol, H-6772 Szeged, Hungary

[6] Univ Szeged, Fac Med, Dept Neurol, H-6725 Szeged, Hungary

关键词: Behavior;    Caffeine;    Cognition;    Dopamine D-2 receptor;    Rat;    Schizophrenia;   

DOI  :  10.1016/j.physbeh.2021.113410

来源: Elsevier

【 摘 要 】

The influence of caffeine on behavioral functions in both healthy and schizophrenic subjects is controversial. Here we aimed to reveal the effects of repeated caffeine pre- and post-training treatments on motor and exploratory activities and cognitive functions in a reward-based test (Ambitus) along with a brain region-specific dopamine D-2 receptor profile in control and schizophrenia-like WISKET model rats. In the control animals, pretreatment caused temporary enhancement in motor activity, while permanent improvement in learning function was detected in the WISKET animals. Post-treatment produced significant impairments in both groups. Caffeine caused short-lasting hyperactivity followed by a rebound in the inactive phase determined in undisturbed circumstance. Caffeine treatment substantially enhanced the dopamine D-2 receptor mediated G-protein activation in the prefrontal cortex and olfactory bulb of both groups, while it increased in the dorsal striatum and cerebral cortex only in the WISKET animals. Caffeine enhanced the maximal binding capacity in the hippocampus and cerebral cortex of WISKET animals, but it decreased in the prefrontal cortex of the control animals. Regarding the dopamine D-2 receptor mRNA expression, caffeine treatment caused significant enhancement in the prefrontal cortex of WISKET animals, while it increased the hippocampal dopamine D-2 receptor protein amount in both groups. This study highlights the disparate effects of caffeine pre- versus post-training treatments on behavioral parameters in both control and schizophrenia-like animals and the prolonged changes in the dopaminergic system. It is supposed that the delayed depressive effects of caffeine might be compensated by frequent coffee intake, as observed in schizophrenic patients.

【 授权许可】

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