Machine learning approaches to the application of disease modifying therapy for sickle cell using classification models

NEUROCOMPUTING

卷:228

Article

Khalaf, Mohammed¹  Hussain, Abir Jaafar¹  Keight, Robert¹  Al-Jumeily, Dhiya¹  Fergus, Paul¹  Keenan, Russell²  Tso, Posco¹ 

[1] Liverpool John Moores Univ, Fac Engn & Technol, Appl Comp Res Grp, Liverpool L3 3AF, Merseyside, England

[2] Alder Hey Childrens Hosp, Haematol Treatment Ctr, Liverpool Paediat Haemophilia Ctr, Eaton Rd, Liverpool L12 2AP, Merseyside, England

关键词: Dynamic neural network;    Elman;    Jordan;    Medical data analysis;    Sickle cell disease;   

DOI  :  10.1016/j.neucom.2016.10.043

来源: Elsevier

【 摘 要 】

This paper discusses the use of machine learning techniques for the classification of medical data, specifically for guiding disease modifying therapies for Sickle Cell. Extensive research has indicated that machine learning approaches generate significant improvements when used for the pre-processing of medical time-series data signals and have assisted in obtaining high accuracy in the classification of medical data. The aim of this paper is to present findings for several classes of learning algorithm for medically related problems. The initial case study addressed in this paper involves classifying the dosage of medication required for the treatment of patients with Sickle Cell Disease. We use different machine learning architectures in order to investigate the accuracy and performance within the case study. The main purpose of applying classification approach is to enable healthcare organisations to provide accurate amount of medication. The results obtained from a range of models during our experiments have shown that of the proposed models, recurrent networks produced inferior results in comparison to conventional feedforward neural networks and the Random Forest model. For our dataset, it was found that the Random Forest Classifier produced the highest levels of performance overall.

【 授权许可】

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