Autistic symptoms predict social cognitive performance in patients with schizophrenia

SCHIZOPHRENIA RESEARCH

卷:215

Article

Deste, Giacomo¹  Vita, Antonio^1,2  Penn, David L.^3,4  Pinkham, Amy E.^5,6  Nibbio, Gabriele²  Harvey, Philip D.^7,8 

[1] Spedali Civili Hosp, Brescia, Italy

[2] Univ Brescia, Sch Med, Brescia, Italy

[3] Univ N Carolina, Dept Psychol, Chapel Hill, NC 27515 USA

[4] Australian Catholic Univ, Sch Psychol, Melbourne, Vic, Australia

[5] Univ Texas Dallas, Sch Behav & Brain Sci, Richardson, TX 75083 USA

[6] Univ Texas Southwestern Med Ctr Dallas, Dept Psychiat, Dallas, TX USA

[7] Univ Miami, Miller Sch Med, Dept Psychiat & Behav Sci, Miami, FL 33136 USA

[8] Miami VA Healthcare Syst, Res Serv, Miami, FL USA

关键词: Schizophrenia;    Schizoaffective;    Autism spectrum disorder;    Social cognition;    PAUSS;    Neurocognition;   

DOI  :  10.1016/j.schres.2019.11.008

来源: Elsevier

【 摘 要 】

Schizophrenia spectrum disorders and Autism Spectrum Disorders (ASD) share many similarities. Among those features, social cognitive impairment is recognized as a key characteristic of both ASD and schizophrenia. In this study, the role of ASD symptoms, measured with the PANSS Autism Severity Score (PAUSS), was investigated as a predictor of social cognitive performance in patients with Schizophrenia spectrum disorders. Existent databases from 2 studies (SCOPE Phase 3 and SCOPE Phase 5), in which a total of 361 patients (mean age 41.7 years; 117 females) were assessed with tests of mental state attribution and emotion recognition, were analyzed. Less severe ASD symptoms, as well as younger age, better premorbid IQ and neurocognition were identified as individual predictors of better social cognitive performance. These results suggest a role of ASD symptoms in affecting social cognitive performance in schizophrenia. (C) 2019 Elsevier B.V. All rights reserved.

【 授权许可】

Free