Increased postural sway predicts negative symptom progression in youth at ultrahigh risk for psychosis

SCHIZOPHRENIA RESEARCH

卷:162

Article

Dean, Derek J.^1,2  Kent, Jerillyn S.^3,4  Bernard, Jessica A.¹  Orr, Joseph M.⁵  Gupta, Tina¹  Pelletier-Baldelli, Andrea^1,2  Carol, Emily E.¹  Mittal, Vijay A.^1,2 

[1] Univ Colorado, Dept Psychol & Neurosci, Boulder, CO 80309 USA

[2] Univ Colorado, Ctr Neurosci, Boulder, CO 80309 USA

[3] Indiana Univ, Dept Psychol & Brain Sci, Bloomington, IN USA

[4] Minneapolis VA Hlth Care Syst, Minneapolis, MN USA

[5] Univ Colorado, Inst Cognit Sci, Boulder, CO 80309 USA

关键词: Postural sway;    Ultrahigh risk;    Cognitive dysmetria;    Psychosis;    Cerebellum;   

DOI  :  10.1016/j.schres.2014.12.039

来源: Elsevier

【 摘 要 】

Impaired ability to maintain an upright posture may reflect impairment in the cerebellum, a critical structure for the fluid coordination of neural information, thought to be disrupted in psychosis. The current study utilized an instrumental measure of posture in individuals at ultrahigh risk (UHR) for psychosis (n = 43) and healthy controls (n = 44). Positive and negative symptoms were assessed twice over 12 months. Results showed that increased postural sway in the UHR group predicted changes in negative symptoms. This study provides an important prospective view on the relationship between cerebellar-sensitive behavior and integral symptoms, which until now has received limited biomarker research. Published by Elsevier B.V.

【 授权许可】

Free