Motor behavior reflects reduced hemispheric asymmetry in the psychosis risk period

SCHIZOPHRENIA RESEARCH

卷:170

Article

Dean, Derek J.^1,2  Orr, Joseph M.³  Newberry, Raeana E.¹  Mittal, Vijay A.⁴ 

[1] Univ Colorado, Dept Psychol & Neurosci, Boulder, CO 80309 USA

[2] Univ Colorado, Ctr Neurosci, Boulder, CO 80309 USA

[3] Texas A&M Univ, Dept Psychol, College Stn, TX 77843 USA

[4] Northwestern Univ, Dept Psychol, Evanston, IL 60208 USA

关键词: Ultrahigh risk;    Psychosis;    Cerebral dominance;    Handwriting;    Laterality;    Dextrality;   

DOI  :  10.1016/j.schres.2015.10.017

来源: Elsevier

【 摘 要 】

Background: A body of work focusing on brain connectivity, language dominance, and motor laterality research suggests that reduced hemispheric asymmetry is a core feature in schizophrenia. However, there is little consensus about whether reduced dominance is present in those at ultrahigh risk (UHR) for psychosis. Methods: A total of 94 demonstrated right-handed neuroleptic free participants (38 UHR and 56 matched healthy controls) were assessed with structured clinical interviews and completed an innovative handwriting task using a digital tablet computer. A laterality quotient (LQ) was calculated using kinematic variables from the participant's left and right hands. A subset of the sample (26 UHR and 29 controls) returned after 12-months to complete clinical interviews in order to examine relationships between handwriting laterality and progression of psychosis risk symptoms. Results: The UHR group showed decreased dextrality compared to healthy controls. At the 12-month follow-up, decreased dextrality accounted for 8% of the variance in worsened positive symptoms within the UHR group. Conclusion: The current results suggest that disrupted cerebral dominance is also present in the ultrahigh risk period and that decreased dextrality may serve as a novel biomarker for the progression of psychosis risk. Published by Elsevier B.V.

【 授权许可】

Free