Psychosis subgroups differ in intrinsic neural activity but not task-specific processing

SCHIZOPHRENIA RESEARCH

卷:195

Article

Hudgens-Haney, Matthew E.^1,2,9  Ethridge, Lauren E.^3,4  McDowell, Jennifer E.^1,2  Keedy, Sarah K.⁵  Pearlson, Godfrey D.^6,7,8  Tamminga, Carol A.⁹  Keshavan, Matcheri S.¹⁰  Sweeney, John A.^9,11  Clementz, Brett A.^1,2 

[1] Univ Georgia, Bioimaging Res Ctr, Dept Psychol, Athens, GA 30602 USA

[2] Univ Georgia, Bioimaging Res Ctr, Dept Neurosci, Athens, GA 30602 USA

[3] Univ Oklahoma, Hlth Sci Ctr, Dept Pediat, Oklahoma City, OK 73190 USA

[4] Univ Oklahoma, Dept Psychol, Norman, OK 73019 USA

[5] Univ Chicago, Dept Psychiat & Behav Neurosci, Chicago, IL 60637 USA

[6] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA

[7] Yale Univ, Sch Med, Dept Neurobiol, New Haven, CT USA

[8] Hartford Hosp, Inst Living, Hartford, CT 06115 USA

[9] UT Southwestern Med Ctr, Dept Psychiat, Dallas, TX USA

[10] Harvard Med Sch, Dept Psychiat, Boston, MA USA

[11] Univ Cincinnati, Dept Psychiat & Behav Neurosci, Cincinnati, OH USA

关键词: Psychosis;    EEG;    Biomarkers;    Schizophrenia;    Bipolar disorder;    Steady-state;   

DOI  :  10.1016/j.schres.2017.08.023

来源: Elsevier

【 摘 要 】

Individuals with psychosis often show high levels of intrinsic, or nonspecific, neural activity, but attenuated stimulus-specific activity. Clementz et al. (2016) proposed that one subgroup of psychosis cases has accentuated intrinsic activity (Biotype-2's) and a different subgroup (Biotype-1's) has diminished intrinsic activity, with both groups exhibiting varying degrees of cognitive deficits. This model was studied by assessing neural activity in psychosis probands (N = 105) during baseline and a 5 second period in preparation for a pro-/anti-saccade task. Steady-state stimuli allowed real-time assessment of modulation of visuocortical investment to different target locations. Psychosis probands as a whole showed poor antisaccade performance. As expected, Biotype-1 showed diminished intrinsic neural activity and the worst behavior, and Biotype-2 showed accentuated intrinsic activity and less deviant behavior. Both of these groups also exhibited less dynamic oscillatory phase synchrony. Biotype-3 showed no neurophysiological differences from healthy individuals, despite a history of psychosis. Interestingly, all psychosis subgroups showed normal (i.e., not different from healthy) preparatory modulation of visuocortical investment as a function of cognitive demands, despite varying levels of task performance. Similar analyses conducted subgrouping cases by psychotic symptomatology revealed fewer and less consistent differences, including no intrinsic activity differences between any clinical subgroup and healthy individuals. This study illustrates that (i) differences in intrinsic neural activity may be a fundamental characteristic of psychosis and need to be evaluated separately from stimulus-specific responses, and (ii) grouping patients based on multidimensional classification using neurobiological data may have advantages for resolving heterogeneity and clarifying illness mechanisms relative to traditional psychiatric diagnoses. (C) 2017 Elsevier B.V. All rights reserved.

【 授权许可】

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