Association between free thyroxine levels and clinical phenotype in first-episode psychosis: a prospective observational study

PeerJ

article

Eloi Gine-Serven¹  Maria Martinez-Ramirez¹  Ester Boix-Quintana¹  Eva Davi-Loscos¹  Nicolau Guanyabens²  Virginia Casado²  Desiree Muriana²  Cristina Torres-Rivas¹  M.J. Cuesta³  Javier Labad¹ 

[1] Department of Mental Health, Hospital de Mataró;Department of Neurology, Hospital de Mataró;Department of Psychiatry, Complejo Hospitalario de Navarra;IdiSNA, Navarra Institute for Health Research;Translational Neuroscience Research Unit I3PT-INc-UAB, Institut de Innovació i Investigació Parc Taulí ,(I3PT), Institut de Neurociències, Universitat Autònoma de Barcelona;Centro de Investigación en Red de Salud Mental

关键词: Biomarkers;    First episode;    Psychosis;    Thyroid;    TSH;    FT4;    Thyroxine;    Schizophrenia;    Schizoaffective;    Bipolar disorder;   

DOI  :  10.7717/peerj.15347

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

AimTo determine whether thyroid hormone levels are associated with a specific clinical phenotype in patients with first-episode psychosis (FEP).MethodsNinety-eight inpatients experiencing FEP and with less than 6 weeks of antipsychotic treatment were included in the study and were followed up for one year. Baseline psychiatric evaluation included assessment of prodromal symptoms, positive and negative symptoms, depressive symptoms, stressful life events and cycloid psychosis criteria. Thyroid function (thyroid-stimulating hormone (TSH) and free thyroxin (FT4)) was determined at admission. Partial correlation analysis was conducted to analyse the correlation between levels of TSH/FT4 and symptoms. Logistic regression was performed to explore the association between psychopathological symptoms, 12-month diagnoses and thyroid hormones while adjusting for covariates.ResultsPatients with prodromal symptomatology showed lower baseline FT4 levels (OR = 0.06; p = 0.018). The duration of untreated psychosis (DUP) was inversely associated with FT4 concentrations (r =  − 0.243; p = 0.039). FEP patients with sudden onset of psychotic symptoms (criteria B, cycloid psychosis) showed higher FT4 levels at admission (OR = 10.49; p = 0.040). Patients diagnosed with affective psychotic disorders (BD or MDD) at the 12-month follow-up showed higher FT4 levels at admission than patients diagnosed with nonaffective psychosis (schizophrenia, schizoaffective) (OR = 8.57; p = 0.042).ConclusionsOur study suggests that higher free-thyroxine levels are associated with a specific clinical phenotype of FEP patients (fewer prodromal symptoms, shorter DUP duration and sudden onset of psychosis) and with affective psychosis diagnoses at the 12-month follow-up.

【 授权许可】

CC BY