Tobacco craving in smokers with and without schizophrenia

SCHIZOPHRENIA RESEARCH

卷:127

Article

Lo, Suzanne²  Heishman, Stephen J.²  Raley, Heather¹  Wright, Katherine¹  Wehring, Heidi J.¹  Moolchan, Eric T.³  Feldman, Stephanie¹  Liu, Fang¹  McMahon, Robert P.¹  Richardson, Charles M.¹  Kelly, Deanna L.¹ 

[1] Univ Maryland, Sch Med, Maryland Psychiat Res Ctr, Baltimore, MD 21228 USA

[2] NIDA, Nicotine Psychopharmacol Sect, NIH, Intramural Res Program, Baltimore, MD 21224 USA

[3] Alkermes Inc, Cambridge, MA 02139 USA

关键词: Schizophrenia;    Nicotine;    Smoking;    Craving;    Dependency;   

DOI  :  10.1016/j.schres.2010.06.017

来源: Elsevier

【 摘 要 】

We examined tobacco craving and dependence in current smokers (18-65 years) with schizophrenia (N = 100) and those without a psychiatric disorder (normal controls, N = 100). During the 2-3 h visit participants completed demographic and smoking-related questionnaires and provided a breath CO sample. The Tobacco Craving Questionnaire-Short Form (TCQ-SF) was administered. Immediately after smoking one cigarette, no difference in TCQ-SF total score was noted (46.7 +/- 19.5 schizophrenia, 42.8 +/- 18.2 controls, p = 0.15); however, after 15 min TCQ-SF total score was significantly higher in people with schizophrenia (50.0 +/- 19.6) than in controls (38.6 +/- 19.4) (p = 0.0014). TCQ-SF factors of emotionality (p = 0.0015), compulsivity (p = 0.0003) and purposefulness (p = 0.0174) were significantly greater in the schizophrenia group than the control group. MID scores (5.5 +/- 2.0 vs 5.3 +/- 2.0, p = 0.62) number of cigarettes smoked daily (17.9 +/- 11.6 vs. 17.0 +/- 7.9), expired breath CO (28.0 +/- 14.5 ppm vs. 22.0 +/- 8.0 ppm) and age at smoking initiation (16.2 +/- 5.4 vs. 15.6 +/- 5.5 years, p = 0.44) did not differ in the schizophrenia and control groups respectively. In conclusion, tobacco craving as measured by the TCQ-SF was significantly greater in people with schizophrenia than controls 15 min post-smoking, despite similar scores in dependence and similar smoking histories and current smoking patterns. (C) 2010 Elsevier B.V. All rights reserved.

【 授权许可】

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