Sex-specific rates of transmission of psychosis in the New England high-risk family study

SCHIZOPHRENIA RESEARCH

卷:128

Article

Goldstein, Jill M.^1,2,3,4,5  Cherkerzian, Sara^1,2,3,4  Seidman, Larry J.^5,6  Petryshen, Tracey L.^7,8  Fitzmaurice, Garrett⁹  Tsuang, Ming T.^6,10,11  Buka, Stephen L.¹² 

[1] Brigham & Womens Hosp, Div Womens Hlth, Dept Psychiat, Connors Ctr Womens Hlth & Gender Biol, Boston, MA 02120 USA

[2] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Dept Med, Boston, MA USA

[4] Brigham & Womens Hosp, Div Womens Hlth, Dept Med, Connors Ctr Womens Hlth & Gender Biol, Boston, MA 02120 USA

[5] Massachusetts Gen Hosp, Dept Psychiat, Div Psychiat Neurosci, Boston, MA 02114 USA

[6] Beth Israel Deaconess Med Ctr, Massachusetts Mental Hlth Ctr, Dept Psychiat, Div Publ Psychiat, Boston, MA 02115 USA

[7] Massachusetts Gen Hosp, Dept Psychiat, Ctr Human Genet Res, Psychiat & Neurodev Genet Unit, Boston, MA 02114 USA

[8] Broad Inst MIT & Harvard, Stanley Ctr Psychiat Res, Boston, MA USA

[9] Harvard Univ, McLean Hosp, Sch Med, Dept Psychiat, Belmont, MA 02178 USA

[10] Univ Calif San Diego, Dept Psychiat, Ctr Behav Genom, San Diego, CA 92103 USA

[11] Harvard Univ, Sch Publ Hlth, Harvard Inst Psychiat Epidemiol & Genet, Boston, MA 02115 USA

[12] Brown Univ, Dept Community Hlth, Providence, RI 02912 USA

关键词: Schizophrenia;    Psychosis;    Genetic transmission;    Sex differences;    High risk;    X-linked inheritance;   

DOI  :  10.1016/j.schres.2011.01.019

来源: Elsevier

【 摘 要 】

Recent molecular genetic studies have demonstrated X-chromosome abnormalities in the transmission of psychosis, a finding that may contribute to understanding sex differences in the disorder. Using our family high risk paradigm, we tested the hypothesis that there are sex-specific patterns of transmission of psychosis and whether there is specificity comparing nonaffective- with affective-type psychoses. We identified 159 parents with psychoses (schizophrenia psychosis spectrum disorders (SPS, n = 59) and affective (AP, n = 100)) and 114 comparable, healthy control parents. 203 high risk (HR) and 147 control offspring were diagnostically assessed (185 females: 165 males). We compared the proportion of male:female offspring with psychoses by affected parent sex and the consistency for SPS compared to AP parents, and tested (using exact logistic regression) whether the male:female ratio for affected offspring differed significantly between affected mothers and affected fathers. Risk of psychosis in offspring was a function of the sex of the parent and offspring. Among ill mothers, 18.8% of their male offspring developed psychosis compared with 9.5% of their daughters. In contrast, among ill fathers, 3.1% of their male offspring developed psychosis compared with 15.2% of their daughters. The male: female ratio for affected offspring differed significantly (p < 0.05) between affected mothers and fathers. Similar patterns held for SPS and AP. Results demonstrated sex-specific transmission of psychosis regardless of psychosis-type and suggest X-linked inheritance. This has important implications for molecular genetic studies of psychoses underscoring the impact of one's gender on gene-brain-behavior phenotypes of SCZ. (C) 2011 Elsevier B.V. All rights reserved.

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