Shape abnormalities of caudate nucleus in schizotypal personality disorder

SCHIZOPHRENIA RESEARCH

卷:110

Article

Levitt, James J.^1,2  Styner, Martin^4,5  Niethammer, Marc^4,5  Bouix, Sylvain²  Koo, Min-Seong⁶  Voglmaier, Martina M.^1,7  Dickey, Chandlee C.^1,2  Niznikiewicz, Margaret A.^1,2  Kikinis, Ron³  McCarley, Robert W.¹  Shenton, Martha E.^1,2,3 

[1] Harvard Univ, Sch Med, Vet Affairs Boston Healthcare Syst, Dept Psychiat,Brockton Div,Lab Neurosci, Brockton, MA 02301 USA

[2] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Psychiat,Psychiat Neuroimaging Lab, Boston, MA 02115 USA

[3] Harvard Univ, Brigham & Womens Hosp, Sch Med,Dept Radiol, Surg Planning Lab,Magnet Resonance Imaging Div, Boston, MA 02115 USA

[4] Univ N Carolina, Dept Comp Sci, Chapel Hill, NC USA

[5] Univ N Carolina, Dept Psychiat, Chapel Hill, NC USA

[6] Kwandong Univ, Coll Med, Seoul, South Korea

[7] Cambridge Hlth Alliance, Dept Psychiat, Cambridge, MA USA

关键词: Schizotypal personality disorder;    Caudate nucleus;    Striatum;    MRI;    Shape;    Spherical harmonics;   

DOI  :  10.1016/j.schres.2008.11.012

来源: Elsevier

【 摘 要 】

Background: Previously, we reported abnormal volume and global shape in the caudate nucleus in schizotypal personality disorder (SPD). Here, we use a new shape measure which importantly permits local in addition to global shape analysis, as well as local correlations with behavioral measures. Methods: Thirty-two female and 15 male SPDs, and 29 female and 14 male normal controls (NCLs), underwent brain magnetic resonance imaging (MRI). We assessed caudate shape measures using spherical harmonic-point distribution model (SPHARM-PDM) methodology. Results: We found more pronounced global shape differences in the right caudate in male and female SPD, compared with NCLs. Local shape differences, principally in the caudate head, survived statistical correction on the right. Also, we performed correlations between local surface deformations with clinical measures and found significant correlations between local shape deflated deformations in the anterior medial surface of the caudate with verbal learning capacity in female SPD. Conclusions: Using SPHARM-PDM methodology, we found both global and local caudate shape abnormalities in male and female SPD, particularly right-sided, and largely restricted to limbic and cognitive anterior caudate. The most important and novel findings were bilateral statistically significant correlations between local surface deflations in the anterior medial surface of the head of the caudate and verbal learning capacity in female SPD. By extension, these local caudate correlation findings implicate the ventromedial prefrontal cortex (vmPFC), which innervates that area of the caudate, and demonstrate the utility of local shape analysis to investigate the relationship between specific subcortical and cortical brain structures in neuropsychiatric conditions. (c) 2008 Published by Elsevier B.V.

【 授权许可】

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