Alcohol use disorders contribute to hippocampal and subcortical shape differences in schizophrenia

SCHIZOPHRENIA RESEARCH

卷:131

Article

Smith, Matthew J.¹  Wang, Lei^1,2  Cronenwett, Will¹  Goldman, Morris B.¹  Mamah, Daniel³  Barch, Deanna M.^3,4,5  Csernansky, John G.¹ 

[1] Northwestern Univ, Feinberg Sch Med, Dept Psychiat & Behav Sci, Chicago, IL 60611 USA

[2] Northwestern Univ, Feinberg Sch Med, Dept Radiol, Chicago, IL 60611 USA

[3] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63130 USA

[4] Washington Univ, Dept Psychol, St Louis, MO 63130 USA

[5] Washington Univ, Sch Med, Dept Radiol, St Louis, MO 63130 USA

关键词: Neuroimaging;    Alcohol;    Shape analysis;    Schizophrenia;   

DOI  :  10.1016/j.schres.2011.05.014

来源: Elsevier

【 摘 要 】

Background: Alcohol abuse and dependence have been reported to exacerbate the clinical course of schizophrenia. However, the neurobiological basis of this co-morbid interaction is unknown. The aim of this study was to determine the relationship of co-morbid alcohol use disorder (AUD) with brain structure abnormalities in schizophrenia patients. Methods: T1-weighted magnetic resonance images were collected from schizophrenia patients without a history of any substance use disorder (SCZ_0, n = 35), schizophrenia patients with a history of AUD only (SCZ_AUD, n = 16), and a healthy comparison group without a history of any substance use disorder (CON, n = 56). Large-deformation, high-dimensional brain mapping was used to quantify the surface shapes of the hippocampus, thalamus, striatum, and globus pallidus in these subject groups. Analysis of variance was used to test for differences in surface shape measures among the groups. Results: SCZ_AUD demonstrated the greatest severity of shape abnormalities in the hippocampus, thalamus, striatum, and globus pallidus as compared to SCZ_0 and CON. SCZ_AUD demonstrated a combination of exaggerated shape differences in regions where SCZ_0 also showed shape differences, and unique shape differences that were not observed in SCZ_0 or CON. Conclusions: Shape differences in schizophrenia were compounded by a history of co-morbid AUD. Future research is needed to determine whether these differences are simply additive or whether they are due to an interaction between the underlying neurobiology of schizophrenia and alcoholism. The consequences of such shape differences for the clinical course of schizophrenia are not yet understood. (C) 2011 Elsevier B.V. All rights reserved.

【 授权许可】

Free