Alteration to hippocampal shape in cannabis users with and without schizophrenia

SCHIZOPHRENIA RESEARCH

卷:143

Article

Solowij, Nadia^1,2  Walterfang, Mark^3,4,5  Lubman, Dan I.⁶  Whittle, Sarah^3,4  Lorenzetti, Valentina^3,4  Styner, Martin^7,8  Velakoulis, Dennis^3,4,5  Pantelis, Christos^3,4  Yuecel, Murat^3,4 

[1] Univ Wollongong, Sch Psychol, Wollongong, NSW 2522, Australia

[2] Schizophrenia Res Inst, Darlinghurst, NSW 2010, Australia

[3] Univ Melbourne, Melbourne Neuropsychiat Ctr, Melbourne, Vic 3010, Australia

[4] Melbourne Hlth, Melbourne, Vic, Australia

[5] Royal Melbourne Hosp, Neuropsychiat Unit, Melbourne, Vic 3050, Australia

[6] Monash Univ, Clayton, Vic 3800, Australia

[7] Univ N Carolina, Dept Psychiat, Chapel Hill, NC USA

[8] Univ N Carolina, Dept Comp Sci, Chapel Hill, NC USA

关键词: Cannabis;    Schizophrenia;    Hippocampus;    Shape analysis;    Neuroimaging;   

DOI  :  10.1016/j.schres.2012.10.040

来源: Elsevier

【 摘 要 】

Abnormalities in hippocampal morphology are characteristic of schizophrenia and have also been reported in chronic cannabis users. There is a paucity of research investigating potential additive effects of cannabis use on brain pathology associated with schizophrenia. In this study, we performed hippocampal shape analysis in cannabis-using and non-using patients with schizophrenia, healthy cannabis users and healthy non-using controls. Hippocampal shape changes were observed in each group relative to controls, with the greatest degree of alterations (i.e., deflations across the hippocampus, and with an anterior predisposition), in cannabis-using schizophrenia patients. These alterations were associated with cannabis use patterns and psychotic symptoms. (C) 2012 Elsevier B.V. All rights reserved.

【 授权许可】

Free