Effects of omega-3 dietary supplement in prevention of positive, negative and cognitive symptoms: A study in adolescent rats with ketamine-induced model of schizophrenia

SCHIZOPHRENIA RESEARCH

卷:141

Article

Gama, Clarissa S.^1,2  Canever, Lara^3,4  Panizzutti, Bruna^1,2  Gubert, Carolina^1,5  Stertz, Laura^1,5  Massuda, Raffael^1,2  Pedrini, Mariana^1,2  de Lucena, David F.^6,7  Luca, Renata D.^3,4  Fraga, Daiane B.^3,4  Heylmann, Alexandra S.^3,4  Deroza, Pedro F.^3,4  Zugno, Alexandra I.^3,4 

[1] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, INCT Translat Med, Lab Mol Psychiat, Porto Alegre, RS, Brazil

[2] Univ Fed Rio Grande do Sul, Programa Posgrad Med Psiquiatria, Porto Alegre, RS, Brazil

[3] Univ Extremo Sul Catarinense, Lab Neurociencias, INCT TM, BR-88806000 Criciuma, SC, Brazil

[4] Univ Extremo Sul Catarinense, Unidade Acad Ciencias Saude, Programa Posgrad Ciencias Saude, NENASC, BR-88806000 Criciuma, SC, Brazil

[5] Univ Fed Rio Grande do Sul, Inst Ciencias Basicas Saude, Programa Posgrad Ciencias Biol Bioquim, Porto Alegre, RS, Brazil

[6] Fac Med Christus, Fortaleza, Ceara, Brazil

[7] Univ Fed Ceara, Dept Fisiol & Farmacol, Lab Neurofarmacol, Fortaleza, Ceara, Brazil

关键词: Omega-3 polyunsaturated fatty acids;    Schizophrenia;    Conversion to psychosis;    Ultra-high risk population;    Animal model;    BDNF;   

DOI  :  10.1016/j.schres.2012.08.002

来源: Elsevier

【 摘 要 】

Omega-3 has shown efficacy to prevent schizophrenia conversion in ultra-high risk population. We evaluated the efficacy of omega-3 in preventing ketamine-induced effects in an animal model of schizophrenia and its effect on brain-derived neurotrophic factor (BDNF). Omega-3 or vehicle was administered in Wistar male rats, both groups at the 30th day of life for 15 days. Each group was split in two to receive along the following 7 days ketamine or saline. Locomotor and exploratory activities, memory test and social interaction between pairs were evaluated at the 52nd day of life. Prefrontal-cortex, hippocampus and striatum tissues were extracted right after behavioral tasks for mRNA BDNF expression analysis. Bloods for serum BDNF were withdrawn 24 h after the end of behavioral tasks. Locomotive was increased in ketamine-treated group compared to control, omega-3 and ketamine plus omega-3 groups. Ketamine group had fewer contacts and interaction compared to other groups. Working memory and short and long-term memories were significantly impaired in ketamine group compared to others. Serum BDNF levels were significantly higher in ketamine plus omega-3 group. There was no difference between groups in prefrontal-cortex, hippocampus and striatum for mRNA BDNF expression. Administration of omega-3 in adolescent rats prevents positive, negative and cognitive symptoms in a ketamine animal model of schizophrenia. Whether these findings are consequence of BDNF increase it is unclear. However, this study gives compelling evidence for larger clinical trials to confirm the use of omega-3 to prevent schizophrenia and for studies to reinforce the beneficial role of omega-3 in brain protection. (C) 2012 Elsevier B.V. All rights reserved.

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