White matter alterations and the conversion to psychosis: A combined diffusion tensor imaging and glutamate1H MRS study

SCHIZOPHRENIA RESEARCH

卷:249

Article

Leon-Ortiz, Pablo^1,2  Reyes-Madrigal, Francisco¹  Kochunov, Peter³  Gomez-Cruz, Gladys¹  Moncada-Habib, Tomas¹  Malacara, Melanie¹  Mora-Duran, Ricardo⁴  Rowland, Laura M.³  de la Fuente-Sandoval, Camilo^1,5 

[1] Inst Nacl Neurol & Neurocirug, Lab Expt Psychiat, Insurgentes Sur 3877, Mexico City 14269, DF, Mexico

[2] Inst Nacl Neurol & Neurocirug, Dept Educ, Mexico City, DF, Mexico

[3] Univ Maryland, Sch Med, Maryland Psychiat Res Ctr, Dept Psychiat, Baltimore, MD USA

[4] Hosp Fray Bernardino Alvarez, Emergency Dept, Mexico City, DF, Mexico

[5] Inst Nacl Neurol & Neurocirug, Neuropsychiat Dept, Mexico City, DF, Mexico

关键词: Clinical high risk;    Conversion to psychosis;    Diffusion tensor imaging;    Glutamate;    Magnetic resonance spectroscopy;   

DOI  :  10.1016/j.schres.2020.06.006

来源: Elsevier

【 摘 要 】

Introduction: Widespread white matter abnormalities and alterations in glutamate levels have been reported in patients with schizophrenia. We hypothesized that alterations in white matter integrity and glutamate levels in individuals at clinical high risk (CHR) for psychosis are associated with the subsequent development of psy-chosis.Methods: Participants included 33 antipsychotic naive CHR (Female 7/Male 26, Age 19.55 (4.14) years) and 38 healthy controls (Female 10/Male 28, Age 20.92 (3.37) years). Whole brain diffusion tensor imaging for fractional anisotropy (FA) and right frontal white matter proton magnetic resonance spectroscopy for glutamate levels were acquired. CHR participants were clinically followed for 2 years to determine conversion to psychosis.Results: CHR participants that transitioned to psychosis (N = 7, 21%) were characterized by significantly lower FA values in the posterior thalamic radiation compared to those who did not transition and healthy controls. In the CHR group that transitioned to psychosis only, positive exploratory correlations between glutamate levels and FA values of the posterior thalamic radiation and the retrolenticular part of the internal capsule and a negative cor-relation between glutamate levels and the cingulum FA values were found.Conclusion: The results of the present study highlight that alterations in white matter structure and glutamate are related with the conversion to psychosis.(c) 2020 Elsevier B.V. All rights reserved.

【 授权许可】

Free